Copper catalyzed halogenaton and reaction products
US9382279B2 · kind B2 · utility
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Key dates
| Filing date | Jun 16, 2014 |
| Grant date | Jul 5, 2016 |
| Priority date | — |
| Expiry date | Jun 16, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F17/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A Cu(I)-catalyzed 1,3-halogen migration reaction effectively recycles an activating group by transferring a halogen from an sp2 to a benzylic carbon with good enantioselectivity and concomitant borylation of the Ar-halo bond. The resulting enantio-enriched benzyl halide can be reacted in the same vessel under a variety of conditions to form an additional carbon-heteroatom or carbon-carbon bond while maintaining high ee. The reaction can be used to efficiently prepare novel compounds and intermediates for the preparation of therapeutics and ligands for catalysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.