Broad spectrum antibiotic compounds and use thereof
US9382294B2 · kind B2 · utility
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25Claims
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Key dates
| Filing date | Feb 28, 2014 |
| Grant date | Jul 5, 2016 |
| Priority date | — |
| Expiry date | Feb 28, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The discovery of a non-ribosomal peptide synthetase (NRPS) gene cluster in the genome of Clostridium thermocellum that produces a secondary metabolite that is assembled outside of the host membrane is described. Also described is the identification of homologous NRPS gene clusters from several additional microorganisms. The secondary metabolites produced by the NRPS gene clusters exhibit broad spectrum antibiotic activity. Thus, antibiotic compounds produced by the NRPS gene clusters, and analogs thereof, their use for inhibiting bacterial growth, and methods of making the antibiotic compounds are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.