CD133 epitopes

US9382308B2 · kind B2 · utility

Assignee

• Cedars Sinai Medical Center · US

Inventors

• John S. Yu · Los Angeles, US
• Keith L. Black · Los Angeles, US
• Gentao Liu · Los Angeles, US

Key dates

• Filing date: Mar 14, 2013
• Grant date: Jul 5, 2016
• Expiry date: Mar 14, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An immunogen includes an isolated peptide of 800 amino acid residues or fewer having the amino sequence ILSAFSVYV (SEQ ID NO: 1) with four or fewer amino acid substitutions, a superagonist variant of SEQ ID NO: 1, or an amino acid sequence having the formula: (I/K/T/V/M)-L-(S/L)-(A/E/N/D/Q)-(F/V)-(S/M/V/I)-(V/D/R/G/H)-Y-(V/I/L) (SEQ ID NO: 13). The immunogens can be used in compositions and in the treatment of disorders.