Expression of triple-helical collagen-like products in E. coli

US9382310B2 · kind B2 · utility

Assignee

• Rutgers, the State University of New Jersey · US

Inventors

• Oleg Mirochnitchenko · Rockville, US
• Masayori Inouye · Bound Brook, US
• Barbara Brodsky · Kendall Park, US
• John Ramshaw · Brunswick, AU

Key dates

• Filing date: Feb 5, 2010
• Grant date: Jul 5, 2016
• Expiry date: Feb 5, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/74
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Recombinant bacterial triple-helical collagen-like proteins comprising two or more repetitive sequences of Gly-Xaa-Yaa yielding high-stability polymeric constructs without the need for post-translational modifications and which may incorporate one or more functional domains of biological or structural importance. The polymers are capable of high-yield production for a variety of applications.