ST2 antigen binding proteins

US9382318B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Dirk E. Smith · Bainbridge Island, US
• Ian Foltz · Burnaby, CA
• Chadwick Terence King · North Vancouver, CA
• Ai Ching Lim · Redwood City, US
• Rutilio Clark · Bainbridge Island, US
• Michael R. Comeau · Seattle, US
• Randal R. Ketchem · Snohomish, US
• Donghui Shi · Thousand Oaks, US
• Xiaoshan MIN · Burlingame, US
• Zhulun Wang · Palo Alto, US

Key dates

• Filing date: May 17, 2013
• Grant date: Jul 5, 2016
• Expiry date: May 17, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.