Multispecific antibodies comprising full length antibodies and single chain fab fragments

US9382323B2 · kind B2 · utility

Assignee

• Roche Glycart AG · CH

Inventors

• Ulrich Brinkmann · Weilheim, DE
• Peter Bruenker · Hittnau, CH
• Rebecca Croasdale · Antdorf, DE
• Christian Klein · Iffeldorf, DE
• Erhard Kopetzki · Penzberg, DE
• Ekkehard Moessner · Kreuzlingen, CH
• Joerg Thomas Regula · Munich, DE
• Juergen Michael Schanzer · Traunstein, DE
• Jan Olaf Stracke · Penzberg, DE
• Pablo Umana · Wollerau, CH

Key dates

• Filing date: Mar 31, 2010
• Grant date: Jul 5, 2016
• Expiry date: Jul 23, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.