Reprogramming of somatic cells

US9382515B2 · kind B2 · utility

Assignee

• Whitehead Institute For Biomedical Research · US

Inventors

• Rudolf Jaenisch · Brookline, US
• Yaqub Hanna · Tel Aviv-Yafo, IL
• Marius Wernig · Woodside, US
• Christopher J. Lengner · Wellesley, US
• Alexander Meissner · Brookline, US
• Oliver Tobias Brambrink · Cambridge, US
• G. Grant Welstead · Cambridge, US
• Ruth Foreman · Somerville, US

Key dates

• Filing date: Apr 7, 2008
• Grant date: Jul 5, 2016
• Expiry date: Apr 7, 2028

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/91011
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.