Pyrrolobenzodiazepines and targeted conjugates
US9387259B2 · kind B2 · utility
24Cited by
48References
22Claims
0Family size
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Key dates
| Filing date | Oct 12, 2012 |
| Grant date | Jul 12, 2016 |
| Priority date | — |
| Expiry date | Oct 12, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.