Method of target membrane protein depletion
US9388243B2 · kind B2 · utility
3Cited by
1References
12Claims
0Family size
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Key dates
| Filing date | May 29, 2014 |
| Grant date | Jul 12, 2016 |
| Priority date | — |
| Expiry date | May 29, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of target membrane protein depletion comprising treating a cell with a dual binding molecule comprising a first binding domain which binds to a driver membrane protein and a second binding domain which binds to a target membrane protein, wherein the cell comprises a cell membrane, and the driver membrane protein and target membrane protein are associated with the cell membrane where the target membrane protein positions, and are internalized into a cell and degraded when the first binding domain of the dual binding molecule binds the driver membrane protein; as well as related methods and compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.