Methods and devices for nucleic acid synthesis
US9388407B2 · kind B2 · utility
58Cited by
20References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 31, 2014 |
| Grant date | Jul 12, 2016 |
| Priority date | — |
| Expiry date | Mar 31, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12M1/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary embodiments, the device includes a support having a plurality of features. Each feature contains a plurality of oligonucleotides. Within each feature, each of the plurality of oligonucleotides includes an identical predetermined subunit sequence of X nucleosides and a degenerate sequence of Y nucleosides. A predetermined combination of a subset of the features can be used to produce a polynucleotide having a predetermined sequence of Z nucleosides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.