Methods and dosage forms for controlled delivery of paliperidone and risperidone

US9393192B2 · kind B2 · utility

Assignee

• ALZA CORPORATION · US

Inventors

• Nyomi V. Yam · Sunnyvale, US
• Iran Reyes · San Jose, US
• Nipun Davar · Fremont, US
• Atul D. Ayer · Palo Alto, US
• Julie Lee · Sunnyvale, US
• Sonya Seroff · San Jose, US
• Suneel Gupta · Sunnyvale, US
• Gayatri Sathyan · Bengaluru, IN

Key dates

• Filing date: Apr 22, 2009
• Grant date: Jul 19, 2016
• Expiry date: Jul 26, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/519
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.