Compounds for targeting drug delivery and enhancing siRNA activity

US9393315B2 · kind B2 · utility

Assignee

• NITTO DENKO CORPORATION · JP

Inventors

• Yoshiro Niitsu · Sapporo, JP
• Joseph E. Payne · San Diego, US
• John A. Gaudette · Poway, US
• Zheng Hou · San Diego, US
• Victor Knopov · Oceanside, US
• Richard P. Witte · San Diego, US
• Mohammad Ahmadian · Carlsbad, US
• Loren A. Perelman · San Diego, US
• Yasunobu Tanaka · Osaka, JP
• Violetta Akopian · Oceanside, US

Key dates

• Filing date: Jun 8, 2012
• Grant date: Jul 19, 2016
• Expiry date: Jun 8, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S977/907
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Here described are compounds consisting of the structure(targeting molecule)m-linker-(targeting molecule)n,wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.