Closed loop flow control of a HPLC constant flow pump to enable low-flow operation
US9393504B2 · kind B2 · utility
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Key dates
| Filing date | Jan 22, 2014 |
| Grant date | Jul 19, 2016 |
| Priority date | — |
| Expiry date | Jan 22, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/324
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method and apparatus for monitoring and controlling nano-scale flow rate of fluid in the operating flow path of a HPLC system provide fluid flow without relying on complex calibration routines to compensate for solvent composition gradients typically used in HPLC. The apparatus and method are used to correct the flow output of a typical, analytical-scale (0.1-5 mL/min) HPLC pump to enable accurate and precise flow delivery at capillary (<0.1 mL/min) and nano-scale (<1 μL/min) HPLC flow rates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.