Amides as pim inhibitors

US9394297B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Victor J. Cee · Thousand Oaks, US
• Frank Chavez · San Diego, US
• Jian Chen · Camarillo, US
• Essa Hu Harrington · Camarillo, US
• Bradley J. Herberich · Newbury Park, US
• Claire L. M. Jackson · Thousand Oaks, US
• Brian Alan LANMAN · Calabasas, US
• Thomas Nguyen · Newbury Park, US
• Mark H. Norman · Thousand Oaks, US
• Liping H. Pettus · Thousand Oaks, US
• Anthony B. Reed · Newbury Park, US
• Adrian L. Smith · Simi Valley, US
• Nuria A. Tamayo · Newbury Park, US
• Andrew Tasker · Simi Valley, US
• Hui-Ling Wang · Thousand Oaks, US
• Bin Wu · Thousand Oaks, US
• Ryan Wurz · Newbury Park, US

Key dates

• Filing date: Feb 27, 2013
• Grant date: Jul 19, 2016
• Expiry date: Mar 9, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.