Device and method for sampling bodily fluid for medical analytes in ultra low concentrations

US9395286B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• Lahey Clinic, Inc. · US

Inventors

• Michael J. Cima · Winchester, US
• Gregory J. Ekchian · Belmont, US
• Christophoros C. Vassiliou · Cambridge, US
• Vincent Liu · Cambridge, US
• Christoph Wald · Nahant, US
• Sebastian Flacke · Nahant, US
• Fredric D. Gordon · Newton, US

Key dates

• Filing date: Dec 30, 2011
• Grant date: Jul 19, 2016
• Expiry date: Dec 30, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/186
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Trapping devices and methods are provided for capturing a medical analyte, in blood or another biological fluid. The device may include a structural substrate and a binding agent, such as an antibody, affixed to the structural substrate, wherein the binding agent is capable of binding or attaching with a medical analyte, such as a viral particle, and the device is configured for placement in a biological cavity or vessel (containing a biological fluid) in a patient. The trapping device, which may be in a twisted coil shape, is configured to trap at least some of the medical analyte, such a viral particle, present in the biological fluid. The method may include deploying a trapping device into the patient's blood vessel; after a period following the deployment, removing the trapping device from the biological cavity or blood vessel; and then analyzing the trapping device for the presence of the medical analyte.