Patent · US Active

Amatoxin-conjugates with improved linkers

US9399681B2 · kind B2 · utility

4Cited by

1References

16Claims

0Family size

Assignee

Heldelberg Pharma GmbH · DE

Inventors

Jan Anderl · Herchenrode, DE
Werner Simon · Seeheim-Jugenheim, DE
Christoph Mueller · Birkenau, DE

Key dates

Filing date	Sep 29, 2011
Grant date	Jul 26, 2016
Priority date	—
Expiry date	Sep 29, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody, connected by a linker comprising a urea moiety, which are useful in the treatment of cancer. In a further aspect the invention relates to pharmaceutical compositions comprising such conjugates.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.