Anti-HIV compound and preparation method and use thereof
US9402819B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Dec 13, 2013 |
| Grant date | Aug 2, 2016 |
| Priority date | — |
| Expiry date | Dec 13, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/4056
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the technical field of chemically synthesized drugs, in particular to an anti-HIV drug or prodrug and preparation method and uses thereof. The compound or prodrug compound of the present invention has a structural formula as represented by formula I. The compounds have anti-HIV-1 and anti-HIV-2 virus activity, and have a C8166 therapeutic index as high as 2081.59 and an H9 therapeutic index as high as 303.03. Furthermore, the compounds have high solubility up to 1290-2845.5 μg/ml in an aqueous solution, and can be formulated into an oral formulation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.