Patent · US Active

Methods for producing virus particles with simplified glycosylation of surface proteins

US9403878B2 · kind B2 · utility

3Cited by

0References

18Claims

0Family size

Assignee

ACADEMIA SINICA · TW

Inventors

Chi-Huey Wong · Village of La Jolla, US
Che Ma · Taipei, TW
Yung-Chieh Tseng · New Taipei, TW

Key dates

Filing date	Nov 4, 2011
Grant date	Aug 2, 2016
Priority date	—
Expiry date	Nov 4, 2031

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/52
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Methods for producing virus particles with simplified glycosylation on structural or surface proteins, such as mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1). When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Such methods may include the use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.