Therapeutic TRAIL fusion protein and preparation and use thereof
US9403892B2 · kind B2 · utility
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4References
14Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 27, 2014 |
| Grant date | Aug 2, 2016 |
| Priority date | — |
| Expiry date | Jan 27, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P21/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to the biotechnology area, and provides a kind of TRAIL chimeric protein, DNA sequence encoding this chimeric protein, vectors comprising this DNA, host cells or transgenic animals that contain one of the vectors, and preparation methods for the said chimeric protein and its applications. The said TRAIL fusion protein from the N to C terminal comprises human leucine zipper sequence, human TRAIL protein, human TRAIL extracellular domain or a fragment thereof. The chimeric protein has significantly enhanced stability, prolonged half-life in animals, increased efficacy and thus has broad application future.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.