Anti-MST1R antibodies and uses thereof

US9403909B2 · kind B2 · utility

Assignee

• DAIICHI SANKYO COMPANY, LIMITED · JP

Inventors

• Reimi Kawaida · Tokyo, JP
• Toshiaki Ohtsuka · Tokyo, JP
• Toshinori Agatsuma · Tokyo, JP
• Philip David Rodley · Tokyo, JP
• Sandra Miller · Munich, DE
• Ulrike Schubert · Birkenfeld, DE

Key dates

• Filing date: Aug 10, 2011
• Grant date: Aug 2, 2016
• Expiry date: Jan 23, 2035

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/9121
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for MST1R, which plays an integral role in various disorders or conditions, such as cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the disclosure also can be used in the diagnostics field, as well as for further investigating the role of MST1R in the progression of disorders associated with tumors. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.