Direct differentiation of cardiomyocytes from embryonic stem cells
US9404085B2 · kind B2 · utility
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Key dates
| Filing date | Oct 12, 2012 |
| Grant date | Aug 2, 2016 |
| Priority date | — |
| Expiry date | May 18, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to the induction of differentiation in human embryonic stem (hES) cells to cardiomyocytes and factors such as prostaglandin I2 (PGI2), Fgf 9, Bmp6, Bmp4, Scf, Igf2, and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from hES cells is also provided wherein the media contains these factors. Genes that are upregulated in the process of cardiomyocyte differentiation are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.