Patent · US Active

Method for cleaving a target RNA using a Cas6 polypeptide

US9404098B2 · kind B2 · utility

37Cited by

4References

11Claims

0Family size

Assignee

University of Georgia Research Foundation, Inc. · US

Inventors

Rebecca M. Terns · Athens, US
Michael P. Terns · Athens, US
Jason Carte · Athens, US

Key dates

Filing date	Nov 5, 2009
Grant date	Aug 2, 2016
Priority date	—
Expiry date	Nov 5, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6806
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Provided herein are methods for cleaving a target RNA polynucleotide. The target RNA polynucleotide includes a Cas6 recognition domain and a cleavage site, and may be based on a repeat from a CRISPR locus. The methods may be practiced in vivo or in vitro. Also provided are polypeptides that have Cas6 endoribonuclease activity in the presence of a target RNA polynucleotide, and methods for using the polypeptides.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.