Thermoresponsive, biodegradable, elastomeric material and uses therefor

US9408855B2 · kind B2 · utility

Assignee

• University of Pittsburgh—Of the Commonwealth System of Higher Education · US

Inventors

• Kazuro Lee Fujimoto · Pittsburgh, US
• Jianjun Guan · Dublin, US
• Zuwei Ma · Woburn, US
• William R. Wagner · Escondido, US

Key dates

• Filing date: Jan 28, 2014
• Grant date: Aug 9, 2016
• Expiry date: Jan 28, 2034

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B33Y80/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are novel biocompatible copolymers and compositions comprising the copolymers. The copolymers are non-toxic and typically have an LCST below 37° C. Compositions comprising the copolymers can be used for wound treatment, as a cellular growth matrix or niche and for injection into cardiac tissue to repair and mechanically support damaged tissue. The copolymers comprise numerous ester linkages so that the copolymers are erodeable in situ. Degradation products of the copolymers are soluble and non-toxic. The copolymers can be amine-reactive so that they can conjugate with proteins, such as collagen. Active ingredients, such as drugs, can be incorporated into compositions comprising the copolymers.