Patent · US Active

Tolvaptan solid dispersion and its preparation method

US9408915B2 · kind B2 · utility

1Cited by
0References
8Claims
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Key dates

Filing dateJun 2, 2011
Grant dateAug 9, 2016
Priority date—
Expiry dateSep 5, 2031

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K9/2077
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A tolvaptan solid dispersion and its preparation method are disclosed. The solid dispersion comprises tolvaptan and cross-linked polyvinylprrolidone at a weight ratio of 1:0.05-20, preferably 1:0.1-10, and more preferably 2:1. The solid dispersion can further comprise one or more water-soluble polymers, such as polyvinylprrolidone, hydroxypropyl cellulose, hydroxyethyl cellulose or methylcellulose, wherein the weight ratio of tolvaptan:the crosslinked polyvinylprrolidone:the water-soluble polymers is preferably 2:1:0.1. The solid dispersion exhibits good thermodynamic stability and solubility. The pharmaceutical composition thereof has improved release rate and bioavailability.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.