FRET-based mesoporous silica nanoparticles for real-time monitoring of drug release
US9408918B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 10, 2014 |
| Grant date | Aug 9, 2016 |
| Priority date | — |
| Expiry date | Aug 23, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5115
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound comprising: (a) a drug carrier comprising coumarin-labeled-cysteine tethered mesoporous silica nanoparticles (MSNs) loaded with a pharmaceutically active agent, and (b) a fluorescein isothiocyanate-β-cyclodextrin (FITC-β-CD) covalently linked to said cysteine and blocking the release of said pharmaceutically active agent from said nanoparticles, wherein cleavage of said covalent linkage removes said cyclodextrin and releases said pharmaceutically active agent, and said coumarin and said fluorescin form a donor-acceptor pair so that said drug carrier has a first emission wavelength when the covalent linkage is intact and the cyclodextrin said present and a second emission wavelength after cleavage of said covalent linkage to remove said cyclodextrin and release said pharmaceutically active agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.