Single step polymerization of covalently bound multilayer matrices
US9409322B2 · kind B2 · utility
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Key dates
| Filing date | Mar 11, 2013 |
| Grant date | Aug 9, 2016 |
| Priority date | — |
| Expiry date | Jun 20, 2034 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB29C64/40
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method is provided for forming complex tissue using density gradient multilayer polymerization (DGMP) to form strong hydrogels with smooth transitions between layers. The multicompartment hydrogel is formed by co-dissolving a polymer precurser with a constituent in multiple solvent fractions to a create prepolymer solutions with different densities, layering the prepolymer solutions on top of each other from high to low solvent density, and irradiating the prepolymer solutions to form a polymer. The hydrogels may be used as biomimetic matrices.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.