Agomelatine sulfuric acid complex, and preparation method and application thereof
US9409857B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | May 14, 2013 |
| Grant date | Aug 9, 2016 |
| Priority date | — |
| Expiry date | May 14, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an Agomelatine sulfuric acid complex in formula (I) and the preparation method thereof (HX=H2SO4, RSO3H (R═CH3, Ph, 4-CH3Ph)). The solubility of the Agomelatine sulfuric acid complex obtained by the method of the present invention is significantly improved compared with Agomelatine, has good stability and higher purity, and is suitable for application in finished-product medicinal preparations. The preparation process is quite simple, and a product with high purity can be obtained without special operations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.