Method for producing 1,4-benzoxazine compound
US9409874B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 8, 2013 |
| Grant date | Aug 9, 2016 |
| Priority date | — |
| Expiry date | Aug 8, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides an industrially advantageous method for producing a 1,4-benzoxazine compound useful as a medicine while avoiding safety and health risks. Specifically, the present invention provides a method for producing a 1,4-benzoxazine compound [A], which comprises the three steps in the following scheme, namely, a step of converting the amino group at 7-position in a compound [a] into a dimesylamino group, a step of coupling a compound [b] with a boronic acid compound, and a step of converting the 7-position in a compound [c] into a monomesylamino group.In the above scheme, Ms is a methanesulfonyl group, and each of R′ and R″ is a hydrogen atom etc.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.