Use of microrna molecules to influence skin pigmentation

US9410152B2 · kind B2 · utility

Assignees

• CHANEL PARFUMS BEAUTE · FR
• INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) · FR
• INSTITUT CURIE · FR
• CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE · FR

Inventors

• Gaelle Saintigny · Paris, FR
• Christian Mahe · Élancourt, FR
• Lionel Larue · Les Ulis, FR
• Florian Rambow · Antony, FR

Key dates

• Filing date: Dec 18, 2012
• Grant date: Aug 9, 2016
• Expiry date: Jan 10, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

At least one microRNA selected from among hsa-miR-330, hsa-miR-7 and hsa-miR-137, the mature forms thereof, and the precursors thereof, for depigmenting the skin, and an in vitro method for identifying depigmenting compounds, which includes the steps of: a) placing at least one test compound in contact with a sample of melanocytes; b) measuring the expression or activity of at least one microRNA selected from among miR-330, miR-7 and miR-137, the mature forms thereof, and the precursors thereof, in the melanocytes; c) selecting the compounds for which at least 20% activation of the expression or of the activity of at least one of the microRNAs is measured in the melanocytes treated in a) by an element for comparing with the untreated melanocytes.