Methods, compositions and screens for therapeutics for the treatment of synovial sarcoma
US9410943B2 · kind B2 · utility
17Cited by
1References
17Claims
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Key dates
| Filing date | Mar 13, 2014 |
| Grant date | Aug 9, 2016 |
| Priority date | — |
| Expiry date | Mar 13, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions are provided for treating human synovial sarcoma (SS). Also provided are screens to identify therapeutics for the treatment of synovial sarcoma. These methods, compositions, and screens are based on the discovery that promoting the assembly of wild type BAF (also called mSWI/SNF) complexes in SS cells by increasing levels of wild type SS18 and/or decreasing levels of SS18-SSX fusion protein leads to the cessation of proliferation of malignant cells in synovial sarcoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.