Process for producing a solid dispersion of an active ingredient

US9414992B2 · kind B2 · utility

Assignee

• Abb Vie Deutschland Gmbh & Co. KG · DE

Inventors

• Thomas Kessler · Schifferstadt, DE
• Jorg Breitenbach · Mannheim, DE
• Christoph Schmidt · Kriftel, DE
• Matthias Degenhardt · Ludwigshafen, DE
• Jörg Rosenberg · Ellerstadt, DE
• Harald Krull · Ludwigshafen, DE
• Gunther Berndl · Herxheim, DE

Key dates

• Filing date: Dec 2, 2013
• Grant date: Aug 16, 2016
• Expiry date: Dec 2, 2033

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B29K2105/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A process for producing a solid dispersion of an active ingredient which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (R; A), (ii) at least one reverse-flight section (D), and (iii) a discharging section (E), wherein the processing elements defining the reverse-flight section (R; D) comprise at least one reverse-flight element (14) which is based on a screw-type element having a conveying direction being opposite to the general conveying direction of the extruder.