Hydropyrrolopyrrole derivatives for use as fatty acid synthase inhibitors

US9416133B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Wolfgang Staehle · Ingelheim am Rhein, DE
• Christos Tsaklakidis · Weinheim, DE
• Birgitta Leuthner · Darmstadt, DE
• Dirk Wienke · Darmstadt, DE
• Frank Czauderna · Dedham, US
• Ansgar Wegener · Heusenstamm, DE

Key dates

• Filing date: Aug 30, 2013
• Grant date: Aug 16, 2016
• Expiry date: Aug 30, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of the formula Iin which R1, R2, R, X1, X2, X3, X4, n1, n2, n3 and n4 have the meanings indicated in claim 1, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.