Patent · US Active

Alphavirus replicon particles matched to protein antigens as immunological adjuvants

US9416370B2 · kind B2 · utility

10Cited by

16References

10Claims

0Family size

Assignee

ALPHAVAX, INC. · US

Inventors

Jonathan F. Smith · Cary, US
Bolyn Hubby · Chapel Hill, US
Laura Copp · Raleigh, US

Key dates

Filing date	Oct 18, 2010
Grant date	Aug 16, 2016
Priority date	—
Expiry date	Feb 18, 2034

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The immune response to an antigen of interest, especially one in purified form, can be significantly enhanced by the simultaneous administration of an alphavirus replicon particle which expresses the same antigen. This allows for the use of significantly smaller quantities of the protein antigen than in conventional immunization strategies, and this new immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.