Chimeric non-human animal carrying human hepatocyte
US9420769B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | Oct 12, 2012 |
| Grant date | Aug 23, 2016 |
| Priority date | — |
| Expiry date | Nov 1, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/03
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A chimeric non-human animal having an in vivo human hepatocyte population, wherein the effects of non-human animal cells on drug metabolism are suppressed or deleted is provided. A method for producing a chimeric non-human animal that lacks a drug-metabolizing system or has a suppressed drug-metabolizing system and is provided with a drug-metabolizing system driven by human hepatocytes, is provided. The method comprises transplanting human hepatocytes into a non-human animal characterized by (i) being immunodeficient, (ii) having liver damage, and (iii) lacking the functions of an endogenous Cyp3a gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.