Nano delivery systems for siRNA

US9421173B2 · kind B2 · utility

Assignee

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL

Inventors

• Simon Benita · Jerusalem, IL
• Orit Amsalem · Jerusalem, IL
• Taher NASSAR · Turan, IL

Key dates

• Filing date: Sep 20, 2012
• Grant date: Aug 23, 2016
• Expiry date: Sep 20, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2810/859
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention makes use of a unique methodology of double nano-encapsulation for protecting and controlling the release of active agents, either hydrophobic or hydrophilic, from stable nanoparticles of opposite characteristics. The protection of the active agent was achieved by loading the agent to be protected, into nanocarriers, which were subsequently encapsulated into sub-micron nanoparticles. The sub-micron nanoparticles formation has been successfully achieved by the use of novel nano spray techniques.