Tripeptide boronic acid or boronic ester, preparative method and use thereof
US9421237B2 · kind B2 · utility
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3References
16Claims
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Key dates
| Filing date | May 17, 2010 |
| Grant date | Aug 23, 2016 |
| Priority date | — |
| Expiry date | May 17, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0821
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses proteasome inhibitors of tripeptide boronic acids or boronic esters represented by Formula (I), preparative method and use thereof. The proteasome inhibitors are therapeutical agents for treating malignant tumor, various nervous system degenerative diseases, muscle cachexia or diabetes, wherein the malignant tumor is leukemia, gastric cancer, hepatocarcinoma or nasopharyngeal carcinoma.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.