Saponin nano micelle, preparing method, application and pharmaceutical composition thereof

US9421269B2 · kind B2 · utility

Assignee

• FUJIAN SOUTH PHARMACEUTICAL CO., LTD. · CN

Inventors

• Huaxing Zhan · Shanghai, CN
• Zhihong Jiang · Ganzhou, CN
• Dan Wang · Beijing, CN
• Xin Shen · Beijing, CN
• Jidong Yang · Shanghai, CN
• Jianping Luo · Fujian, CN
• Hongsheng Zhang · San Diego, US
• Min Du · Santa Clara, US
• Pengfei Miao · Shanghai, CN

Key dates

• Filing date: Dec 4, 2013
• Grant date: Aug 23, 2016
• Expiry date: Jan 11, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2800/413
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A saponin nano micelle, preparing method, application and pharmaceutical composition thereof is disclosed in the present invention. The saponin nano micelle comprises one or more of saponins represented by formula 1, in which, R1 and R2 are independently —H or a hydrophilic group, R3 is —H or —OH, R4 is a lipophilic group. The preparing method of the saponin nano micelle is that mixing the saponin with an organic solvent which can dissolve saponin, and then removing the organic solvent. The saponin micelle acts as a convey medium of the drug ingredients, and can replace conventional drug carriers such as pharmaceutical solubilizers or polymeric micelle, which has high safety and great significance. The pharmaceutical ingredients can prolong circulation time and biological half-life of drug in the blood, and increase the accumulation of drug in lesions, and reduce adverse reactions.