ICMT inhibitors

US9422238B2 · kind B2 · utility

Assignee

• NATIONAL UNIVERSITY OF SINGAPORE · SG

Inventors

• Pondy Murugappan Ramanujulu · Singapore, SG
• Tianming Yang · Singapore, SG
• Mei-Wang Casey · Singapore, SG
• Patrick J. Casey · Durham, US
• Mei Lin Go · Singapore, SG

Key dates

• Filing date: May 30, 2013
• Grant date: Aug 23, 2016
• Expiry date: May 30, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention provides a 1,3,5-substituted indole wherein the substituent at position 1 is a C6 to C12 alkyl group; the substituent at position 3 is CH2NR1R2 wherein R1 is H or C1 to C3 alkyl, R1 being optionally substituted with —OH, —SH, —NH2 or NHalkyl, wherein alkyl is a C1 to C4 alkyl group, and R2 is C1 to C3 alkyl or (CH2)n bonded to position 2 of the indole, wherein n is 1, 2 or 3; and the substituent at position 5 is either an optionally substituted nitrogen containing heteroaromatic ring or an aminosulfonylphenyl group or an alkylsulfonylphenyl group.