Benzopiperazine compositions as BET bromodomain inhibitors

US9422281B2 · kind B2 · utility

Assignee

• FORMA Therapeutics, Inc. · US

Inventors

• Kenneth W. Bair · Chapel Hill, US
• Torsten Herbertz · Stow, US
• Goss S. Kauffman · Ledyard, US
• Katherine J. Kayser-Bricker · Branford, US
• George P. Luke · Clinton, US
• Matthew W. Martin · Arlington, US
• David S. Millan · Watertown, US
• Shawn Schiller · Haverhill, US
• Adam Charles Talbot · Guilford, US
• Mark J. Tebbe · Hamburg, DE

Key dates

• Filing date: Nov 18, 2014
• Grant date: Aug 23, 2016
• Expiry date: Nov 18, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to inhibitors of bromo and extra terminal (BET) br’omodomains that are useful for the treatment of cancer, inflammatory diseases, diabetes, and obesity, having Formula (I):wherein X, Y, Z, R1, R2, R4 and R7 are defined herein.