Patent · US Active

Synthetic scFv analogue to the 6313/G2 (anti angiotensin II type 1 receptor) monoclonal antibody variable regions

US9422369B2 · kind B2 · utility

0Cited by

1References

8Claims

0Family size

Assignee

Queen Mary & Westfield College · GB

Inventors

Gavin Paul Vinson · London, GB
Stewart Barker · Aberdeen, GB
John Richard Puddefoot · London, GB

Key dates

Filing date	Jun 20, 2013
Grant date	Aug 23, 2016
Priority date	—
Expiry date	Jun 20, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/76
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a specific binding molecule which specifically binds to a peptide having the amino acid sequence of EDGIKRIQDD and comprises a polypeptide having an immunoglobulin VL domain linked to an immunoglobulin VH domain in which the VL domain comprises Complementarity Determining Regions (CDRs) VLCDR1, VLCDR2 and VLCDR3, and in which the VH domain comprises Complementarity Determining Regions (CDRs) VHCDR1, VHCDR2, VHCDR3, each having a respective amino acid sequence as follows in which VHCDR1 is GYSFTGYNMN VHCDR2 is NIDPYYGGTTYNQKFKG VHCDR3 is EVDY VLCDR1 is RASKSVSTSTSGYSYMH VLCDR2 is LVSNLES VLCDR3 is QHIRELTRSEG or an amino acid sequence at least 70% identical thereto.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.