Patent · US Active

Modified siNA

US9422552B2 · kind B2 · utility

0Cited by

0References

9Claims

0Family size

Assignee

QIAGEN GmbH · DE

Inventors

Peter Hahn · Bensberg, DE
Eric Lader · Boyds, US
Wolfgang Bielke · Mechernich, DE
Alexander Azzawi · Solingen, DE
Jie Kang · Bonn, DE

Key dates

Filing date	Jun 11, 2010
Grant date	Aug 23, 2016
Priority date	—
Expiry date	Jun 27, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/51
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention pertains to the use of at least one abasic modification within the first 8 nucleotide positions of the 5′ region of the antisense strand of a small interfering nucleic acid (siNA) molecule for reducing off-target effects. Provided are suitable modified siNAs, compositions and methods for producing respective siNAs, as well as kits comprising respective siNAs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.