Assay for histidinyl hydroxylase activity
US9422589B2 · kind B2 · utility
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Key dates
| Filing date | Jul 25, 2012 |
| Grant date | Aug 23, 2016 |
| Priority date | — |
| Expiry date | Oct 19, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/90245
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to assays for monitoring activity of Mina53 and NO66 activities, in particular, to assays for identifying modulators of Mina53 and NO66 activities. The invention also relates to assays to monitor the histidinyl hydroxylase activity of Mina53 and NO66 on their substrates, the human ribosomal protein Rpl27a and Rpl8 respectively. The invention also enables the introduction of S-3-hydroxyhistidinyl residues into peptides and proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.