Patent · US Active

Mechanical phenotyping of single cells: high throughput quantitative detection and sorting

US9423234B2 · kind B2 · utility

2Cited by

18References

22Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Amy Rowat · Cambridge, US
David J. Hoelzle · Columbus, US
Clara Chan · Los Angeles, US

Key dates

Filing date	Mar 13, 2013
Grant date	Aug 23, 2016
Priority date	—
Expiry date	Oct 3, 2033

Classification

Technology area (CPC G)Physics
CPC primaryG01N2291/02827
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

This invention provides methods and devices for the high-throughput characterization of the mechanical properties of cells or particles. In certain embodiments the devices comprise a microfluidic channel comprising: an oscillating element on a first side of the channel; and a detecting element on a second side of the channel opposite the oscillating element, wherein the detecting element is configured to detect a force transmitted through a cell or microparticle by the oscillating element. In certain embodiments the devices comprise a microfluidic channel comprising an integrated oscillator and sensor element on one first side of the channel, wherein the sensor is configured to detect a force transmitted through a cell or microparticle by the oscillator.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.