Magnetic microbubbles, methods of preparing them and their uses
US9427396B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 26, 2009 |
| Grant date | Aug 30, 2016 |
| Priority date | — |
| Expiry date | Dec 14, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K49/223
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a method of preparing a suspension of microbubbles for use in a carrier liquid, wherein the microbubbles have a gas core and a liquid shell, said liquid shell comprising magnetic nanoparticles, and wherein the microbubbles satisfy the following conditions: (i) the force due to buoyancy (FBW) of the microbubble in the carrier liquid is greater than the weight (W) of the microbubble; (ii) the magnetic force (FM) on the microbubble due to a magnetic field applied to the carrier liquid is greater than the combined weight (W) and force due to buoyancy (FBW) of the microbubble; (iii) said magnetic force (FM) on the microbubble is greater than the force due to viscous drag (FD) on the microbubble due to flow of the carrier liquid; and (iv) the scattering cross section (σscat) of the microbubble to ultrasound allows the microbubble to be detectable and rupturable on exposure to ultrasound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.