Fluoroalkyl and fluorocycloalkyl 1,4-benzodiazepinone compounds

US9427442B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Yufen Zhao · Pennington, US
• Ashvinikumar V. Gavai · Princeton Junction, US
• Patrice Gill · Fort Lee, US
• Soong-Hoon Kim · Titusville, US
• Brian E. Fink · Yardley, US
• Libing Chen · Newtown, US
• Mark G. Saulnier · Haddam, US
• Wen-Ching Han · Newtown, US

Key dates

• Filing date: Sep 20, 2013
• Grant date: Aug 30, 2016
• Expiry date: Sep 20, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D243/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I): (Formula (I)) wherein: R1 is —CH2CH2CF3; R2 is —CH2CH2CH2F, —CH2CF2CH3, —CH2CH2CF3, —CH2CH(CH3)CF3, —CH2CH2CF2CH3, (Formulae (II), (III), (IV), (V) or (VI): R3 is H or —CH3; Ring A is phenyl or pyridinyl; and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer.