Controlled release compositions for modulating free-radical induced damage and methods of use thereof

US9427472B2 · kind B2 · utility

Assignees

• OTONOMY, INC. · US
• The Regents of the University of California · US

Inventors

• Jay Lichter · Rancho Santa Fe, US
• Andrew M. Trammel · Olathe, US
• Fabrice Piu · San Diego, US
• Qiang Ye · San Diego, US
• Sergio G. Duron · San Diego, US
• Luis A. Dellamary · San Marcos, US
• Carl Lebel · Malibu, US
• Jeffrey P. Harris · Village of La Jolla, US

Key dates

• Filing date: May 1, 2014
• Grant date: Aug 30, 2016
• Expiry date: May 1, 2034

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/7007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).