Modified nucleosides, nucleotides, and nucleic acids, and uses thereof

US9428535B2 · kind B2 · utility

Assignee

• Moderna Therapeutics, Inc. · US

Inventors

• Antonin de Fougerolles · Waterloo, BE
• Atanu Roy · Stoneham, US
• Jason P. Schrum · Philadelphia, US
• Suhaib Siddiqi · Raleigh, US
• Paul Hatala · Boston, US
• Stephane Bancel · Cambridge, US

Key dates

• Filing date: Oct 3, 2012
• Grant date: Aug 30, 2016
• Expiry date: Sep 15, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/67
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one or more chemical modifications and a Protein:Cytokine ratio of greater than 100.