Control of whole body energy homeostasis by microRNA regulation
US9428749B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 9, 2012 |
| Grant date | Aug 30, 2016 |
| Priority date | — |
| Expiry date | Nov 8, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/3231
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure provides a method of regulating fatty acid or glucose metabolism in a cell by contacting the cell with a modulator of miR-208a and/or miR-208b activity or expression. The disclosure also provides a method of treating or preventing a metabolic disorder, such as obesity, diabetes, or metabolic syndrome, in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression. Also provided is a method of enhancing or improving mitochondrial function and/or redox-homeostasis in a subject by administering to the subject an inhibitor of miR-208a and/or miR-208b activity or expression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.