Classification of kinase inhibitors using nonlinear optical techniques
US9428789B2 · kind B2 · utility
3Cited by
132References
18Claims
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Key dates
| Filing date | Mar 21, 2012 |
| Grant date | Aug 30, 2016 |
| Priority date | — |
| Expiry date | Mar 21, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method is disclosed for classifying and distinguishing between type I and type II kinase inhibitors. The method involves the use of non-linear optical techniques, in particular second-harmonic generation (SHG) to identify conformational changes in kinase proteins obtained from known type I or type II inhibitors. The method further involves deducing the manner of binding of unknown inhibitors by comparison with the signal changes produced by known ligands. The method is also applied to comparing the conformational changes induced by the binding of generic and branded kinase inhibitor drugs to a target kinase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.