Method for preparing linezolid intermediate

US9434702B2 · kind B2 · utility

Assignees

• Zhejiang Hisun Pharmaceutical Co., Ltd. · CN
• SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY · CN

Inventors

• Fuli Zhang · Shanghai, CN
• Chunbo Yang · Shantou, CN
• Bin Liang · Bositenghu, CN
• Pengcheng Qiu · 东关南街, CN
• Hairong Luo · Zhejiang, CN
• Jiang Li · Spartanburg, US
• Jian Chai · Zhejiang, CN
• Qingfeng Cai · 流花街道, CN

Key dates

• Filing date: Feb 8, 2013
• Grant date: Sep 6, 2016
• Expiry date: Mar 1, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a new method for preparing a methyl substitute of a linezolid intermediate, (S)-2-(3-(3-fluoro-4-morpholinophenyl)-2-oxo-5-oxazoline) (I), wherein the intermediate (I) is obtained by the cyclization of 3-fluoro-4-morpholinophenyl isocyanate (II) and epoxy compound (III). This process has a short process route, low cost, easy operation, and high yield, so is suitable for a large-scale industrial production.